stressosome
2016-05-08 04:07:14 0 举报
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Stressosome是一个由多种蛋白质组成的复合物，它在细胞内起到调节应激反应的作用。当细胞受到外部刺激时，如紫外线、高温或化学物质等，stressosome会被激活并启动一系列信号通路，以保护细胞免受损伤。这些信号通路包括NF-κB、MAPK和JNK等，它们可以促进细胞凋亡、自噬和DNA修复等过程，从而维持细胞的稳定性。然而，如果stressosome过度活跃或失调，就可能导致细胞死亡或癌症的发生。因此，对stressosome的研究对于理解应激反应机制以及开发新的治疗策略具有重要意义。
作者其他创作
大纲/内容
bofilm formation
C-terminal
C-Terminal
catalytic phoaphatase
2c protein phosphatase
Kinase recruitment
globin-like domain
a signal transduction cascade
STAS domain
secondary messenger
20 protruding \"turrets\"
transmition
RsbT
N-terminal
RsbR
signal integration
RsbV
Stressosome
Bacillus Subtilis
RsbR 146-274:RsbS complex
1.8 MDa
conserved Core
20 dimersRsbR
a global response to the imposed stress
10 dimers RsbS
orchestrate a single signaling outcome
D2 symmetry
Upregulation of the general stress regulon
Ser59 Thr 171 Thr 205
a tunable and cooperative response
RsbU
RsbW
N-Terminal
switch Kinase
RsbS
Regulator of sigma B(Rsb)
Rsb:RsbR:RsbT
sensory extensions
a multiprotein signaling hub
Regulation of aerotxis
Icosahedral symmetry
The activation of the general stress Sigma factor
integrate multiple physical stress signals
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