RCT
2018-06-16 16:02:48 53 举报某随机对照实验的实验对象和方法流程图
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inclusion criteria:1. BMI ≥ 30 kg/m22. age 20–50 years3. with conserved weight during the last 6 months
Anthropometric measurements&Laboratory tests
double-blind
outpatient clinics during February 2013 and July 2013
2h before bed time
randomly assigned
low calorie diet
melatonin group(n = 23)
6 mg/d melatonin
one subject consumed less than 90% of the planned number of tablets because of taking tranquilizers and was excluded from the study
40 days
46 obese women
one subject withdrew because of failure to follow weight loss diet
placebo group(n = 23)
6 mg/d placebo
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