b cell
2023-10-31 21:30:43 4 举报AI智能生成
b cell
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development
negative selection
rearrangement of heavy chain and light chain
coupled with gene rearrangement
enzymes
Rag-1,Rag-2
Tdt
regulation
allelic
isotype exclusion
surface markers
BCR complex
BCR(mlg)
lgα/lgβ(CD79a/CD79b)
Co-receptors
CD19/CD21/CD81complex
CD21
抗原非共价与C3d结合，与CD21结合
BCR与共受体复合物交联，放大BCR接受信号
降低活化阈值，增加B细胞敏感性
II型补体受体
EB病毒受体
感染B细胞，导致B细胞的持续增值和转化
体外建立B淋巴母细胞 长期保存B 细胞克隆
CD81
单抗可抑制淋巴细胞增殖
Co-stimulatory molecules
CD40
B细胞活化的第二信号
对B细胞分化和抗体产生以及类别转换有重要作用
与CD40L
与CD40L结合 可促进APC上调B7促进T细胞活化
CD80,CD86
ICAM-1,LFA-1
分支主题
phases and types of humoral immune respone
B2 cells (TD-Ag)
requirement for Th cell help
mainly lgG
cell -mediated immunity,humoral immunity
memory T and memory B
B1 cells (TI-Ag)
independent of Th cell help
mainly lgM
no cell-madiated,no memory
子主题
phases and types of humoral immune respone
phases
antigen recognition phase
B cells activated by Ag(first signal)
BCR complex
coreceptors(CD21/CD19/CD81)
Th cell-mediated activation and differentiation of B cells
further activation
Th cells→CD40L second signal
B cells→CD40
cytokines(IL-2,IFN-γ,IL-4,IL-5,IL-6,IL-13,etc.).
formation of germinal center
affinity maturation
heavy chain class switching
proliferation and differentiation
effector phase
types
B2→TD-Ag
B1→TI-Ag
functions
子主题
rearrangement of heavy chain and light chain
couple with gene rearrangement
enzymes for rearrangement-- Rag-1,Rag-2 and Tdt
子主题
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